hrp0089p3-p128 | Fat, Metabolism and Obesity P3 | ESPE2018

Exposure to Bisphenol-A and Phtalates in Obese Girls

Deodati Annalisa , Bottaro Giorgia , Fintini Danilo , Tait Sabrina , Maranghi Francesca , Busani Luca , Rocca Cinzia La , Tassinari Roberta , Carli Fabrizia , Latta Veronica Della , Buzzigoli Emma , Gastaldelli Amalia , Cianfarani Stefano

Background: The increasing incidence of obesity is a global public health challenge. Although energy imbalance is the major cause of obesity, evidence suggests that other risk factors such as exposure to endocrine-disrupting chemicals (EDCs) may contribute to the development of obesity. Early life exposure to obesogens may result in a higher risk of developing obesity. Among the chemicals suspected to have obesogenic effects, bisphenol A (BPA) and phthalates are under worldwid...

hrp0089p1-p209 | Pituitary, Neuroendocrinology and Puberty P1 | ESPE2018

Exposure to BPA and Phthalates and Timing of Puberty in Girls

Deodati Annalisa , Bottaro Giorgia , Tait Sabrina , Maranghi Francesca , Busani Luca , Rocca Cinzia La , Tassinari Roberta , Carli Fabrizia , Latta Veronica Della , Buzzigoli Emma , Gastaldelli Amalia , Cianfarani Stefano

Background: Over the past several decades, the age of pubertal onset in girls has shifted downward worldwide. Exposure to endocrine disrupting chemicals (EDCs) during critical windows of development may play a role in this trend. Epidemiological and animal studies showed that exposure to phthalates and BPA could be associated with earlier puberty onset in girls.Objective: To investigate the association between the exposure to BPA, DEHP’s metabolites...